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Table III.

Baseline characteristics of the stage 2 patients with MSM given either saline or l-arginine


Saline infusion groupa
l-arginine infusion group
Number 48 30 
Age (y):
     mean (range) 28 (18–56) 28 (18–54) 
Males:
     no. (%) 32 (67) 20 (67) 
Weight (kg):
     mean (range) 58 (43–77) 58 (42–70) 
Ethnicity: no.
     (%) Papuan highlander 37 (77) 23 (77) 
Current smoker:
     no. (%) 19 (40) 11 (37) 
Exsmoker:
     no. (%) 7 (14) 4 (13) 
Days of fever before presentation:
     median (IQR) 2 (1–5) 2 (1–4) 
Systolic blood pressure (mmHg):
     mean (range) 114 (88–152) 109 (90–138) 
Hypertensive on enrollment (%) 
Pulse rate (beats/min):
     mean (range) 86 (56–118) 80 (54–116) 
Respiratory rate (breaths/min):
     mean (range) 25 (14–42) 24 (18–32) 
Temperature (°C):
     mean (range) 36.5 (34.1–39.8) 37 (34.8–40.2) 
White blood cell count (×103 μl−1):
     mean (range) 5.9 (2.6–10.8) 6.2 (2.3–11.7) 
Hemoglobin (g/liter):
     mean (95% CI) 128 (7.1–16.7) 123 (7.5–17) 
Plasma l-arginine (μmol/liter):
     mean (95% CI) 42 (37–45) 37 (33–43) 
Lactate concentration (mmol/liter):
     mean (95% CI) 1.29 (1.1–1.5) 1.5 (1.2–1.8) 
RH-PAT index:
     mean (95% CI) 1.82 (1.7–2.02) 1.76 (1.62–1.9) 
Exhaled NO (ppb):
     mean (range) 20.5 (6.2–77.1) 21.2 (4.2–51.3) 
Parasite density (μl−1):
     geometric mean (range) 16,297 (850–227,350) 17,221 (890–281,864) 
HRP2 concentration (loge ng/ml):
     mean (range) 5.78 (1.7–8.79) 5.76 (1.34–8.79) 
Time (h) from start of antimalarial
     therapy to physiological testing:
     mean (95% CI) 4.5 (3–6) 6 (4.5–7.5) 

Saline infusion groupa
l-arginine infusion group
Number 48 30 
Age (y):
     mean (range) 28 (18–56) 28 (18–54) 
Males:
     no. (%) 32 (67) 20 (67) 
Weight (kg):
     mean (range) 58 (43–77) 58 (42–70) 
Ethnicity: no.
     (%) Papuan highlander 37 (77) 23 (77) 
Current smoker:
     no. (%) 19 (40) 11 (37) 
Exsmoker:
     no. (%) 7 (14) 4 (13) 
Days of fever before presentation:
     median (IQR) 2 (1–5) 2 (1–4) 
Systolic blood pressure (mmHg):
     mean (range) 114 (88–152) 109 (90–138) 
Hypertensive on enrollment (%) 
Pulse rate (beats/min):
     mean (range) 86 (56–118) 80 (54–116) 
Respiratory rate (breaths/min):
     mean (range) 25 (14–42) 24 (18–32) 
Temperature (°C):
     mean (range) 36.5 (34.1–39.8) 37 (34.8–40.2) 
White blood cell count (×103 μl−1):
     mean (range) 5.9 (2.6–10.8) 6.2 (2.3–11.7) 
Hemoglobin (g/liter):
     mean (95% CI) 128 (7.1–16.7) 123 (7.5–17) 
Plasma l-arginine (μmol/liter):
     mean (95% CI) 42 (37–45) 37 (33–43) 
Lactate concentration (mmol/liter):
     mean (95% CI) 1.29 (1.1–1.5) 1.5 (1.2–1.8) 
RH-PAT index:
     mean (95% CI) 1.82 (1.7–2.02) 1.76 (1.62–1.9) 
Exhaled NO (ppb):
     mean (range) 20.5 (6.2–77.1) 21.2 (4.2–51.3) 
Parasite density (μl−1):
     geometric mean (range) 16,297 (850–227,350) 17,221 (890–281,864) 
HRP2 concentration (loge ng/ml):
     mean (range) 5.78 (1.7–8.79) 5.76 (1.34–8.79) 
Time (h) from start of antimalarial
     therapy to physiological testing:
     mean (95% CI) 4.5 (3–6) 6 (4.5–7.5) 

There was no significant difference (P < 0.05) between groups for any of the variables.

a

The patients with MSM given saline were those enrolled in stage 1 of the study.

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