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Table I

What Proteins Make Chloride Channels?

Proposed channel proteinChloride channel?Initial reference
  Weight of evidence   
GABA, glycine  Yes  Grenninglogh et al., 1987; Schofield et al., 1987  
CFTR  Yes  Riordan et al., 1989  
CIC class  CIC-2  CIC-3  Yes Perhaps ICl.swell Perhaps ICl.swell  Jentsch et al., 1990,Grunder et al., 1992,Duan et al., 1997  
P-glycoprotein, or multidrug resistance (MDR) gene product  Not a C1 channel  Valverde et al., 1992  
PICln  Not a Cl channel  Paulmichl et al., 1992  
p64  Insufficient evidence  Landry et al., 1993  
Phospholemman  Insufficient evidence  Moorman et al., 1992  
Ca-CC (ICa.Cl?)  Insufficient evidence  Cunningham et al., 1995  
Proposed channel proteinChloride channel?Initial reference
  Weight of evidence   
GABA, glycine  Yes  Grenninglogh et al., 1987; Schofield et al., 1987  
CFTR  Yes  Riordan et al., 1989  
CIC class  CIC-2  CIC-3  Yes Perhaps ICl.swell Perhaps ICl.swell  Jentsch et al., 1990,Grunder et al., 1992,Duan et al., 1997  
P-glycoprotein, or multidrug resistance (MDR) gene product  Not a C1 channel  Valverde et al., 1992  
PICln  Not a Cl channel  Paulmichl et al., 1992  
p64  Insufficient evidence  Landry et al., 1993  
Phospholemman  Insufficient evidence  Moorman et al., 1992  
Ca-CC (ICa.Cl?)  Insufficient evidence  Cunningham et al., 1995  
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