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Table I

Values of the Parameters of the Model Activation Pathway

Transition		z_α		z_β		α₀(ms⁻¹)		β₀(ms⁻¹)
0–1		0.35		0.94		1.57		0.19
1–2, 2–3, 3–4		0.53		0.44		9		1.26
4–5		0.5		0.38		1.14		2.18
5–6, Model 1A		2.81		1.69		50.3		0.023
5–6, Models 2, 3		2.81		1.69		74.6		0.058
6–7, Model 1A		0.3		0.38		1.7		1.1
6–7, Models 2, 3		0.3		0.38		1.7		0.88
O↔ C_f		0		0.17		0.6		3.8
O↔ I_N, Model 1A		0.035		0.2		1.13		0.021
O↔ I_N, Model 2		0.01		0.2		1.14		0.04
O↔ I_N, Model 3		0.01		0.2		1.02		0.052
I_N↔ I_C, Model 2		0		0		0.012		0.024
I_N↔ I_C, Model 3		0		0		0.024		0.022

Transition		z_α		z_β		α₀(ms⁻¹)		β₀(ms⁻¹)
0–1		0.35		0.94		1.57		0.19
1–2, 2–3, 3–4		0.53		0.44		9		1.26
4–5		0.5		0.38		1.14		2.18
5–6, Model 1A		2.81		1.69		50.3		0.023
5–6, Models 2, 3		2.81		1.69		74.6		0.058
6–7, Model 1A		0.3		0.38		1.7		1.1
6–7, Models 2, 3		0.3		0.38		1.7		0.88
O↔ C_f		0		0.17		0.6		3.8
O↔ I_N, Model 1A		0.035		0.2		1.13		0.021
O↔ I_N, Model 2		0.01		0.2		1.14		0.04
O↔ I_N, Model 3		0.01		0.2		1.02		0.052
I_N↔ I_C, Model 2		0		0		0.012		0.024
I_N↔ I_C, Model 3		0		0		0.024		0.022

Additional parameters for Model 3 were: W₄ = 0.1, W₅ = 2.85, and W₆ = 1.93.