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Table III

Intramembranous Charge Movement and Voltage Steepness of Release

(1)(2)(3)(4)(5)(6)(7)(8)
FibernAverage [CaSR]Release permeability−Q OFF(−45) mean (SEM)−Q OFF(−20) mean (SEM)Q OFF(−45) ÷ Q OFF(−20) mean (SEM)Voltage-steepness factor mean (SEM)
    μM  %/ms  nC/μF  nC/μF    mV 
[CaSR] between 1,100 and 1,900 μM         
 509971   1519  0.0072  19.8 (0.2)  28.2 (0.3)  0.705 (0.005)  3.50 (0.14) 
 510971   1412  0.0232  19.6 (0.7)  27.9 (0.7)  0.704 (0.032)  3.47 (0.06) 
 513971   1415  0.0048  20.0 (1.4)  30.3 (1.6)  0.659 (0.012)  3.50 (0.27) 
 514972   1563  0.0033  19.3 (0.5)  29.8 (0.8)  0.649 (0.0003)  3.44 (0.04) 
 515971   1491  0.0087  20.6 (0.2)  29.3 (0.2)  0.703 (0.002)  2.90 (0.22) 
 516972   1435  0.0395  25.4 (0.0)  34.2 (0.1)  0.742 (0.003)  3.47 (0.08) 
 724972   1526  0.0033  19.0 (0.4)  29.5 (0.2)  0.642 (0.008)  3.74 (0.42) 
 Mean    1480  0.0129  20.5  29.9  0.686  3.43 
 SEM         0.8   0.8  0.014  0.10 
[CaSR] near peak of release permeability vs. [CaSR] curve       
 509971    277  0.0350  19.6 (0.4)  29.1 (0.6)  0.675 (0.020)  3.09 (0.09)* 
 510971    304  0.1114  19.8 (0.3)  30.0 (0.9)  0.664 (0.024)  3.21 (0.09)* 
 513971    336  0.0268  19.6 (0.7)  28.6 (0.2)  0.684 (0.023)  3.42 (0.31) 
 514972    335  0.0145  20.3 (0.8)  31.0 (0.7)  0.656 (0.021)  2.77 (0.10)* 
 515971    270  0.0861  22.2 (0.4)*  33.8 (1.2)*  0.658 (0.011)*  2.53 (0.14) 
 516972    176  0.3094  24.5 (0.5)  33.8 (0.2)  0.726 (0.014)  3.76 (0.20) 
 724972    293  0.0149  17.2 (0.6)  27.6 (0.4)*  0.603 (0.014)  3.20 (0.18) 
 Mean     284  0.0855  20.5  30.6  0.667  3.14 
 SEM         0.9   0.9  0.014  0.15 
[CaSR] at smallest values obtained           
 509971     96  0.0121  19.7 (0.4)  30.6 (0.7)  0.646 (0.026)  3.62 (0.84) 
 510971     71  0.0270  18.1 (0.8)  28.4 (1.0)  0.638 (0.025)  3.80 (0.27) 
 513971     78  0.0074  19.7 (0.2)  31.9 (0.3)*  0.618 (0.006)  — 
 514972     94  0.0074  20.8 (1.7)  33.7 (0.8)  0.616 (0.036)  — 
 515971     38  0.0271  25.5 (1.3)  42.7 (2.3)*  0.599 (0.013)*  3.61 (0.41)* 
 516972     59  0.0487  25.3 (0.6)  34.6 (0.9)  0.733 (0.030)  3.22 (0.13) 
 724972     77  0.0076  18.3 (0.4)  28.8 (0.6)  0.635 (0.010)  — 
 Mean      73  0.0196  21.1  33.0  0.641  3.56 
 SEM         1.2   1.8  0.017  0.12 
(1)(2)(3)(4)(5)(6)(7)(8)
FibernAverage [CaSR]Release permeability−Q OFF(−45) mean (SEM)−Q OFF(−20) mean (SEM)Q OFF(−45) ÷ Q OFF(−20) mean (SEM)Voltage-steepness factor mean (SEM)
    μM  %/ms  nC/μF  nC/μF    mV 
[CaSR] between 1,100 and 1,900 μM         
 509971   1519  0.0072  19.8 (0.2)  28.2 (0.3)  0.705 (0.005)  3.50 (0.14) 
 510971   1412  0.0232  19.6 (0.7)  27.9 (0.7)  0.704 (0.032)  3.47 (0.06) 
 513971   1415  0.0048  20.0 (1.4)  30.3 (1.6)  0.659 (0.012)  3.50 (0.27) 
 514972   1563  0.0033  19.3 (0.5)  29.8 (0.8)  0.649 (0.0003)  3.44 (0.04) 
 515971   1491  0.0087  20.6 (0.2)  29.3 (0.2)  0.703 (0.002)  2.90 (0.22) 
 516972   1435  0.0395  25.4 (0.0)  34.2 (0.1)  0.742 (0.003)  3.47 (0.08) 
 724972   1526  0.0033  19.0 (0.4)  29.5 (0.2)  0.642 (0.008)  3.74 (0.42) 
 Mean    1480  0.0129  20.5  29.9  0.686  3.43 
 SEM         0.8   0.8  0.014  0.10 
[CaSR] near peak of release permeability vs. [CaSR] curve       
 509971    277  0.0350  19.6 (0.4)  29.1 (0.6)  0.675 (0.020)  3.09 (0.09)* 
 510971    304  0.1114  19.8 (0.3)  30.0 (0.9)  0.664 (0.024)  3.21 (0.09)* 
 513971    336  0.0268  19.6 (0.7)  28.6 (0.2)  0.684 (0.023)  3.42 (0.31) 
 514972    335  0.0145  20.3 (0.8)  31.0 (0.7)  0.656 (0.021)  2.77 (0.10)* 
 515971    270  0.0861  22.2 (0.4)*  33.8 (1.2)*  0.658 (0.011)*  2.53 (0.14) 
 516972    176  0.3094  24.5 (0.5)  33.8 (0.2)  0.726 (0.014)  3.76 (0.20) 
 724972    293  0.0149  17.2 (0.6)  27.6 (0.4)*  0.603 (0.014)  3.20 (0.18) 
 Mean     284  0.0855  20.5  30.6  0.667  3.14 
 SEM         0.9   0.9  0.014  0.15 
[CaSR] at smallest values obtained           
 509971     96  0.0121  19.7 (0.4)  30.6 (0.7)  0.646 (0.026)  3.62 (0.84) 
 510971     71  0.0270  18.1 (0.8)  28.4 (1.0)  0.638 (0.025)  3.80 (0.27) 
 513971     78  0.0074  19.7 (0.2)  31.9 (0.3)*  0.618 (0.006)  — 
 514972     94  0.0074  20.8 (1.7)  33.7 (0.8)  0.616 (0.036)  — 
 515971     38  0.0271  25.5 (1.3)  42.7 (2.3)*  0.599 (0.013)*  3.61 (0.41)* 
 516972     59  0.0487  25.3 (0.6)  34.6 (0.9)  0.733 (0.030)  3.22 (0.13) 
 724972     77  0.0076  18.3 (0.4)  28.8 (0.6)  0.635 (0.010)  — 
 Mean      73  0.0196  21.1  33.0  0.641  3.56 
 SEM         1.2   1.8  0.017  0.12 

The three sections of this table give results for points near the plateau level, the maximum, and the minimal levels of the release permeability vs. [CaSR] curves. Column 1 gives the fiber references. Column 2 gives the number of points used in the determinations of columns 3–8. Column 3 gives the average value of [CaSR]. Column 4 gives the average of the release permeability at −60 mV. Columns 5 and 6 give the means and SEMs of the −Q OFF values for the pulses to −45 and −20 mV, respectively (see Fig. 7). Column 7 gives the mean and SEM of the ratio of the OFF charges at −45 and −20 mV. Column 8 gives the mean and SEM of the e -fold voltage-steepness factor of the release permeability for the pulses between −70 and −60 mV as described for Fig. 8. Asterisks indicate significant difference from the corresponding average value in the previous section of the table (see text for details).  

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