Table 2

ΔΔG Values for Interactions between μ-CTX Derivatives and Different Na+ Channel Mutants

E403QN40RT759IM1240AD1241AD1532N
 kcal/mol kcal/mol kcal/mol kcal/mol kcal/mol kcal/mol 
D12A 0.14 ± 0.12 (35) 0.54 ± 0.12 (34) −0.29 ± 0.17 (31) −0.12 ± 0.14 (35) ND ND 
Q14D −0.29 ± 0.09 (31) 0.09 ± 0.11 (29) 0.83 ± 0.12 (33) ND ND −0.21 ± 0.09 (42) 
K16A −0.96 ± 0.08 (30) −0.36 ± 0.09 (27) 0.69 ± 0.12 (29) 0.17 ± 0.09 (31) ND −1.39 ± 0.09 (41) 
Hyp17P −0.37 ± 0.09 (31) −0.26 ± 0.10 (30) 0.22 ± 0.13 (29) −0.97 ± 0.10 (35) 0.20 ± 0.09 (37) −0.24 ± 0.10 (39) 
R1A ND ND −1.00 ± 0.12 ND ND ND 
   (31)    
E403QN40RT759IM1240AD1241AD1532N
 kcal/mol kcal/mol kcal/mol kcal/mol kcal/mol kcal/mol 
D12A 0.14 ± 0.12 (35) 0.54 ± 0.12 (34) −0.29 ± 0.17 (31) −0.12 ± 0.14 (35) ND ND 
Q14D −0.29 ± 0.09 (31) 0.09 ± 0.11 (29) 0.83 ± 0.12 (33) ND ND −0.21 ± 0.09 (42) 
K16A −0.96 ± 0.08 (30) −0.36 ± 0.09 (27) 0.69 ± 0.12 (29) 0.17 ± 0.09 (31) ND −1.39 ± 0.09 (41) 
Hyp17P −0.37 ± 0.09 (31) −0.26 ± 0.10 (30) 0.22 ± 0.13 (29) −0.97 ± 0.10 (35) 0.20 ± 0.09 (37) −0.24 ± 0.10 (39) 
R1A ND ND −1.00 ± 0.12 ND ND ND 
   (31)    
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