Rockefeller University Press

Table I.

V_H repertoire analysis of the peripheral B cell subsets of two 11-mo-old children

Donor	B cell subset	Transcripts	Number of peaks  analyzed^{^a}	Total number of  sequences	Number of different  VDJ junctions	Clonal  diversity^{^b}	P value^{^c}
						%
D1	IgD⁺CD27⁺	V_H6 μ	4	104	92	88
	Naive	V_H6 μ	4	56	45	80
	Switched	V_H6 γ	4	67	18	27	10⁻¹⁵
D2	IgD⁺CD27⁺	V_H3.15 μ	4	82	52	63
	Naive	V_H3.15 μ	4	84	52	62
	Switched	V_H3.15 γ	2	40	2	5	4 × 10⁻⁹

Donor	B cell subset	Transcripts	Number of peaks  analyzed^{^a}	Total number of  sequences	Number of different  VDJ junctions	Clonal  diversity^{^b}	P value^{^c}
						%
D1	IgD⁺CD27⁺	V_H6 μ	4	104	92	88
	Naive	V_H6 μ	4	56	45	80
	Switched	V_H6 γ	4	67	18	27	10⁻¹⁵
D2	IgD⁺CD27⁺	V_H3.15 μ	4	82	52	63
	Naive	V_H3.15 μ	4	84	52	62
	Switched	V_H3.15 γ	2	40	2	5	4 × 10⁻⁹

The peaks that were analyzed are identified by an asterisk in Fig. 1.

Number of different VDJ among all the sequences.

Statistical significance (see Materials and methods) of differences in clonal diversity between IgD⁺CD27⁺ and switched cells from the same donor.