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Table I.

VH repertoire analysis of the peripheral B cell subsets of two 11-mo-old children

Donor
B cell subset
Transcripts
Number of peaks
 analyzeda
Total number of
 sequences
Number of different
 VDJ junctions
Clonal
 diversityb
P valuec






%

D1 IgD+CD27+ VH6 μ 104 92 88  
 Naive VH6 μ 56 45 80  
 Switched VH6 γ 67 18 27 10−15 
D2 IgD+CD27+ VH3.15 μ 82 52 63  
 Naive VH3.15 μ 84 52 62  
 Switched VH3.15 γ 40 4 × 10−9 
Donor
B cell subset
Transcripts
Number of peaks
 analyzeda
Total number of
 sequences
Number of different
 VDJ junctions
Clonal
 diversityb
P valuec






%

D1 IgD+CD27+ VH6 μ 104 92 88  
 Naive VH6 μ 56 45 80  
 Switched VH6 γ 67 18 27 10−15 
D2 IgD+CD27+ VH3.15 μ 82 52 63  
 Naive VH3.15 μ 84 52 62  
 Switched VH3.15 γ 40 4 × 10−9 
a

The peaks that were analyzed are identified by an asterisk in Fig. 1.

b

Number of different VDJ among all the sequences.

c

Statistical significance (see Materials and methods) of differences in clonal diversity between IgD+CD27+ and switched cells from the same donor.

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