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Table II.

VH3.15 repertoire analysis of the splenic B cell subsets of an 8-mo-old child

Donor
B cell subset
Transcripts
Number of peaks
 analyzeda
Total number of
 sequences
Number of different
 VDJ junctions
Clonal
 diversityb
P valuec






%

D3 IgD+CD27+ VH3.15 μ 58 56 97  
 Naives VH3.15 μ 71 64 90  
 IgDCD27+
 (switched + GC) VH3.15 γ 73 35 48 3 × 10−9 
 CD38+CD24
 (GC) VH3.15 μ 133 71 53 4 × 10−9 
  VH3.15 γ 98 51 52 10−8 
Donor
B cell subset
Transcripts
Number of peaks
 analyzeda
Total number of
 sequences
Number of different
 VDJ junctions
Clonal
 diversityb
P valuec






%

D3 IgD+CD27+ VH3.15 μ 58 56 97  
 Naives VH3.15 μ 71 64 90  
 IgDCD27+
 (switched + GC) VH3.15 γ 73 35 48 3 × 10−9 
 CD38+CD24
 (GC) VH3.15 μ 133 71 53 4 × 10−9 
  VH3.15 γ 98 51 52 10−8 
a

The peaks that were analyzed are identified by an asterisk in Fig. 2.

b

Number of different VDJ among all sequences.

c

Statistical significance (see Materials and methods) of differences in clonal diversity between IgD+CD27+ and IgDCD27+ or GC cells from the same donor.

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