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Table III.

VH6 repertoire analysis of the splenic B cell subsets of an 8-mo-old child

Donor
B cell subset
Transcripts
Number of peaks
 analyzeda
Total number of
 sequences
Number of different
 VDJ junctions
Clonal
 diversityb
P valuec






%

D3 IgD+CD27+ VH6 μ 68 58 85  
 Naives VH6 μ 56 36 64  
 IgDCD27+
 (switched + GC) VH6 γ 50 12 24 7 × 10−11 
 CD38+CD24
 (GC) VH6 μ 55 14.5 2 × 10−14 
  VH6 γ 76 6.5 10−20 
Donor
B cell subset
Transcripts
Number of peaks
 analyzeda
Total number of
 sequences
Number of different
 VDJ junctions
Clonal
 diversityb
P valuec






%

D3 IgD+CD27+ VH6 μ 68 58 85  
 Naives VH6 μ 56 36 64  
 IgDCD27+
 (switched + GC) VH6 γ 50 12 24 7 × 10−11 
 CD38+CD24
 (GC) VH6 μ 55 14.5 2 × 10−14 
  VH6 γ 76 6.5 10−20 
a

The peaks that were analyzed are identified by an asterisk in Fig. 2.

b

Number of different VDJ among all sequences.

c

Statistical significance (see Materials and methods) of differences in clonal diversity between IgD+CD27+ and IgDCD27+ or GC cells from the same donor.

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