Functional analysis of WT and SPARC-null mice after MI
| Sham | MI, 3 d | MI, 7 d | MI, 14 d | |||||
| WT, n = 12 (M/F: 6/6) | null, n = 13 (M/F: 4/9) | WT, n = 10 (M/F: 5/5) | null, n = 11 (M/F: 5/6) | WT, n = 7 (M/F: 3/4) | null, n = 7 (F: 7) | WT, n = 9 (F: 9) | null, n = 9 (F: 9) | |
| FS (%) | 26 ± 1.3 | 30 ± 2.2 | 14 ± 3.1b | 16 ± 2.6b | 18 ± 3.1b | 15 ± 7b | 12 ± 1.4b | 12 ± 1.2b |
| LVIDd (mm) | 3.7 ± 0.1 | 3.6 ± 0.1 | 4.2 ± 0.2b | 4.1 ± 0.2b | 4.7 ± 0.2b | 4.9 ± 0.5b | 5.0 ± 0.3b | 5.3 ± 0.2b |
| LVIDs (mm) | 2.8 ± 0.1 | 2.5 ± 0.1 | 3.6 ± 0.2b | 3.5 ± 0.2b | 3.9 ± 0.3b | 4.3 ± 0.6b | 4.4 ± 0.3b | 4.7 ± 0.3b |
| PWd (mm) | 1.0 ± 0.1 | 0.9 ± 0.1 | 0.7 ± 0.1b | 0.8 ± 0.1b | 0.8 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 |
| IVSd (mm) | 0.9 ± 0.1 | 1.0 ± 0.1 | 0.7 ± 0.1b | 0.9 ± 0.1a | 1.0 ± 0.2 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 |
| HW/BW | 5.2 ± 0.2 | 5.2 ± 0.2 | 5.6 ± 0.2 | 5.8 ± 0.3 | 7.0 ± 0.3b | 7.9 ± 0.8b | 6.4 ± 0.1b | 7.2 ± 0.3ab |
| LW/BW | 6.4 ± 0.4 | 5.9 ± 0.2 | 6.4 ± 0.2 | 7.4 ± 0.3ab | 9.7 ± 1.3b | 10 ± 1.2b | 10 ± 1.3b | 9.8 ± 1.2b |
| Sham | MI, 3 d | MI, 7 d | MI, 14 d | |||||
| WT, n = 12 (M/F: 6/6) | null, n = 13 (M/F: 4/9) | WT, n = 10 (M/F: 5/5) | null, n = 11 (M/F: 5/6) | WT, n = 7 (M/F: 3/4) | null, n = 7 (F: 7) | WT, n = 9 (F: 9) | null, n = 9 (F: 9) | |
| FS (%) | 26 ± 1.3 | 30 ± 2.2 | 14 ± 3.1b | 16 ± 2.6b | 18 ± 3.1b | 15 ± 7b | 12 ± 1.4b | 12 ± 1.2b |
| LVIDd (mm) | 3.7 ± 0.1 | 3.6 ± 0.1 | 4.2 ± 0.2b | 4.1 ± 0.2b | 4.7 ± 0.2b | 4.9 ± 0.5b | 5.0 ± 0.3b | 5.3 ± 0.2b |
| LVIDs (mm) | 2.8 ± 0.1 | 2.5 ± 0.1 | 3.6 ± 0.2b | 3.5 ± 0.2b | 3.9 ± 0.3b | 4.3 ± 0.6b | 4.4 ± 0.3b | 4.7 ± 0.3b |
| PWd (mm) | 1.0 ± 0.1 | 0.9 ± 0.1 | 0.7 ± 0.1b | 0.8 ± 0.1b | 0.8 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 |
| IVSd (mm) | 0.9 ± 0.1 | 1.0 ± 0.1 | 0.7 ± 0.1b | 0.9 ± 0.1a | 1.0 ± 0.2 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 |
| HW/BW | 5.2 ± 0.2 | 5.2 ± 0.2 | 5.6 ± 0.2 | 5.8 ± 0.3 | 7.0 ± 0.3b | 7.9 ± 0.8b | 6.4 ± 0.1b | 7.2 ± 0.3ab |
| LW/BW | 6.4 ± 0.4 | 5.9 ± 0.2 | 6.4 ± 0.2 | 7.4 ± 0.3ab | 9.7 ± 1.3b | 10 ± 1.2b | 10 ± 1.3b | 9.8 ± 1.2b |
M, male; F, female; FS, fractional shortening; LVIDd, left ventricular internal diameter diastole; PWd, posterior wall diastole; IVSd, intraventricular septum diastole; HW, heart weight; BW, body weight; and LW, lung weight.
P < 0.05 in SPARC-null versus WT infarcts.
P < 0.05 in infarcted versus sham.