Histological analysis of the infarcted area of AdR5- and AdSPARC-treated mice
| AdR5 MI, 14 d (n = 9) | AdSPARC MI, 14 d (n = 9) | |
| Infarct size (%) | 35 ± 3.9 | 38 ± 1.4 |
| Residual necrotic area (%) | 1.5 ± 2.3 | 2.1 ± 1.5 |
| Infarct thickness (µm) | 450 ± 16 | 520 ± 28 |
| Leukocyte infiltration (cells/mm2) | 570 ± 91 | 560 ± 91 |
| Coronary growth (vessels/mm2) | 32 ± 4 | 35 ± 3 |
| Capillary growth (vessels/mm2) | 106 ± 11 | 113 ± 9 |
| Myofibroblast (% area) | 1.0 ± 0.2 | 1.6 ± 0.2 |
| Collagen deposition (%) | 28 ± 2.3 | 40 ± 2.5a |
| Ratio O-R thick/Y-G thin collagen fibers | 18 ± 3.7 | 60 ± 11a |
| AdR5 MI, 14 d (n = 9) | AdSPARC MI, 14 d (n = 9) | |
| Infarct size (%) | 35 ± 3.9 | 38 ± 1.4 |
| Residual necrotic area (%) | 1.5 ± 2.3 | 2.1 ± 1.5 |
| Infarct thickness (µm) | 450 ± 16 | 520 ± 28 |
| Leukocyte infiltration (cells/mm2) | 570 ± 91 | 560 ± 91 |
| Coronary growth (vessels/mm2) | 32 ± 4 | 35 ± 3 |
| Capillary growth (vessels/mm2) | 106 ± 11 | 113 ± 9 |
| Myofibroblast (% area) | 1.0 ± 0.2 | 1.6 ± 0.2 |
| Collagen deposition (%) | 28 ± 2.3 | 40 ± 2.5a |
| Ratio O-R thick/Y-G thin collagen fibers | 18 ± 3.7 | 60 ± 11a |
O-R, orange-red; Y-G, yellow-green.
P < 0.05 in AdvSPARC infarcts versus AdR5 infarcts.