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Table I.

Effects of treatment with anti–CC chemokine antibodies on the survival of D6−/− mice to M. tuberculosis infection

Weeks after infection
Mice
Treatment
8
12
16
WT Nil 0/10 0/10 0/10 
D6−/− Nil 3/10 5/10 9/10 
D6−/− Control antibody 2/10 4/10 9/10 
D6−/− Anti-CCL2/MCP-1 3/10 3/10 8/10 
D6−/− Anti-CCL3/MIP-1α 4/10 6/10 9/10 
D6−/− Anti-CCL4/MIP-1β 2/10 4/10 8/10 
D6−/− Anti-CCL5/RANTES 2/10 4/10 9/10 
D6−/− Mix antibody 0/10* 1/10* 3/10** 
Weeks after infection
Mice
Treatment
8
12
16
WT Nil 0/10 0/10 0/10 
D6−/− Nil 3/10 5/10 9/10 
D6−/− Control antibody 2/10 4/10 9/10 
D6−/− Anti-CCL2/MCP-1 3/10 3/10 8/10 
D6−/− Anti-CCL3/MIP-1α 4/10 6/10 9/10 
D6−/− Anti-CCL4/MIP-1β 2/10 4/10 8/10 
D6−/− Anti-CCL5/RANTES 2/10 4/10 9/10 
D6−/− Mix antibody 0/10* 1/10* 3/10** 

WT mice and D6−/− mice either untreated or treated with monoclonal antibodies to single individual CC chemokines, or with a cocktail of anti–CC chemokines (mix antibody) or irrelevant control antibodies, were infected with M. tuberculosis. Mice were scored for survival over time. Data shown are the numbers of deaths out of the number of treated mice (n = 10 per group). *, P < 0.001; and **, P < 0.01 when compared with values in D6−/− mice either untreated (Nil) or treated with control antibody.

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