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Table I.

SNPs in the region flanking CTGF are associated with severe HF in two Chinese samples

     Chinese fishermen Chinese farmers 
 SNP Position Bins Genotype Controls Cases OR 95% CI Controls Cases OR 95% CI 
     % %    % %    
Univariate analysis rs1257705 132304944 II AA 69.1 83.7 2.26 1.13–4.5 0.02 65.1 72 1.67 0.98–2.84 0.06 
 rs12526196 132305169 II TT 67.9 82.5 2.21 1.13–4.4 0.02 61.6 71.8 1.85 1.1–3.1 0.02 
 rs9399005 132310657  CC 17.2 26.3 2.2 1.1–4.29 0.02     NS 
 rs6918698 132314950 III CC 26.6 35.1 1.1–3.7 0.02     NS 
 rs3037970 132316891 III −/− 27.3 38.8 2.59 1.4–4.8 0.003     NS 
 rs1931002 132320175 IV CC 52.5 66.7 2.32 1.3–4.13 0.004     NS 
 rs2151532 132316423 IV AA 55.4 65 1.98 1.12–3.5 0.02     NS 
 rs9402373 132319124 VI CC 50.3 60.6 2.04 1.15–3.54 0.015 25 43.1 2.23 1.32–3.76 0.003 
Multivariate analysis rs12526196  II TT   1.4–6.6 0.007   1.88 1.13–3.19 0.018 
 rs9402373  VI CC   2.8 1.5–5.4 0.002   2.26 1.33–3.83 0.03 
 rs1931002  IV CC   2.81 1.47–5.37 0.002      
     Chinese fishermen Chinese farmers 
 SNP Position Bins Genotype Controls Cases OR 95% CI Controls Cases OR 95% CI 
     % %    % %    
Univariate analysis rs1257705 132304944 II AA 69.1 83.7 2.26 1.13–4.5 0.02 65.1 72 1.67 0.98–2.84 0.06 
 rs12526196 132305169 II TT 67.9 82.5 2.21 1.13–4.4 0.02 61.6 71.8 1.85 1.1–3.1 0.02 
 rs9399005 132310657  CC 17.2 26.3 2.2 1.1–4.29 0.02     NS 
 rs6918698 132314950 III CC 26.6 35.1 1.1–3.7 0.02     NS 
 rs3037970 132316891 III −/− 27.3 38.8 2.59 1.4–4.8 0.003     NS 
 rs1931002 132320175 IV CC 52.5 66.7 2.32 1.3–4.13 0.004     NS 
 rs2151532 132316423 IV AA 55.4 65 1.98 1.12–3.5 0.02     NS 
 rs9402373 132319124 VI CC 50.3 60.6 2.04 1.15–3.54 0.015 25 43.1 2.23 1.32–3.76 0.003 
Multivariate analysis rs12526196  II TT   1.4–6.6 0.007   1.88 1.13–3.19 0.018 
 rs9402373  VI CC   2.8 1.5–5.4 0.002   2.26 1.33–3.83 0.03 
 rs1931002  IV CC   2.81 1.47–5.37 0.002      

Data are provided for two independent Chinese samples (fishermen and farmers living in a region endemic for S. japonicum). Cases and controls were defined as indicated in Materials and methods and in Table S1. The association between genotypes and HF phenotypes were first tested separately (univariate analysis) and then simultaneously (multivariate analysis that included SNPS rs12526196, rs1931002, rs3037970, and rs9402373, which showed the strongest associations when tested against SNPs from the same bin). Bins represented correlation (r2 > 0.8) groups, and genotype was the aggravating genotype. In the Chinese fisherman sample (n = 300, 99 cases and 201 controls), the covariates were the number of years of fishing, being born on a boat, sex, and the number of Praziquantel treatments. In the Chinese farmer sample (n = 294, 113 controls and 181 cases), the covariates were age, whether HF was endemic or not endemic, and whether they had been infected with HBV (P = 0.05; OR = 2.38). P, p-value.

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