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Table I.

Loss of infectivity of PbeIK2 (-) sporozoites in C57BL/6 mice

Infected by		Wild type		PbeIK2 (-)
		Infected/total	PPDs (no. of mice)	Infected/total	PPDs (no. of mice)
Mosquito bite^a		6 / 6	3 (6)	0 / 6
		6 / 6	3 (6)	1 / 16	7(1)
Intravenous injection	10,000^b	12 / 12	3(12)	5 / 12	7(2), 8(3)
	1,000^b	6 / 6	4(6)	0 / 6

Infected by		Wild type		PbeIK2 (-)
		Infected/total	PPDs (no. of mice)	Infected/total	PPDs (no. of mice)
Mosquito bite^a		6 / 6	3 (6)	0 / 6
		6 / 6	3 (6)	1 / 16	7(1)
Intravenous injection	10,000^b	12 / 12	3(12)	5 / 12	7(2), 8(3)
	1,000^b	6 / 6	4(6)	0 / 6

Pre-patent day (PPD), Number of days after sporozoite inoculation until detection of erythrocytic stages by microscopic examination of blood smears.

10 infected mosquitoes per mouse. Shown are results of two independent experiments.

No. of injected sporozoites.