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Table 1.

Effect of leukocyte ABCA1 and ABCG1 deficiencies on body weight, plasma leptin levels, subcutaneous and retroperitoneal adipose depots, plasma glucose, insulin and TNF levels, epididymal adipose tissue cellularity, and energy metabolism

Metabolic parameters BM transplantation 
 WT Abca1−/−Abcg1−/− 
Body weight (g) 27.9 ± 0.9 27.4 ± 0.6 
Plasma Leptin (ng/ml) 1.95 ± 0.4 0.7 ± 0.2* 
Subcutaneous fat mass (g) 0.52 ± 0.12 0.15 ± 0.03* 
Retroperitoneal fat mass (g) 0.28 ± 0.04* 0.09 ± 0.08* 
Plasma glucose (g/liter) 2.1 ± 0.1 1.7 ± 0.1* 
Plasma Insulin (ng/ml) 7.9 ± 0.8 6.1 ± 1.1 
Plasma TNF (pg/ml) 3.1 ± 0.5 7.4 ± 0.6* 
Fat cell number (×1064.8 ± 0.9 4.6 ± 0.8 
Fat cell weight (ng) 119 ± 14* 36 ± 5* 
Food intake (g/day) 3.28 ± 0.14 3.33 ± 0.13 
Food intake (g/day/g0.750.29 ± 0.01 0.29 ± 0.01 
Energy expenditure, EE (W/kg0.756.68 ± 0.25 7.11 ± 0.18 
Locomotor activity (counts/14 min) 2,589 ± 544 2,560 ± 499 
Metabolic parameters BM transplantation 
 WT Abca1−/−Abcg1−/− 
Body weight (g) 27.9 ± 0.9 27.4 ± 0.6 
Plasma Leptin (ng/ml) 1.95 ± 0.4 0.7 ± 0.2* 
Subcutaneous fat mass (g) 0.52 ± 0.12 0.15 ± 0.03* 
Retroperitoneal fat mass (g) 0.28 ± 0.04* 0.09 ± 0.08* 
Plasma glucose (g/liter) 2.1 ± 0.1 1.7 ± 0.1* 
Plasma Insulin (ng/ml) 7.9 ± 0.8 6.1 ± 1.1 
Plasma TNF (pg/ml) 3.1 ± 0.5 7.4 ± 0.6* 
Fat cell number (×1064.8 ± 0.9 4.6 ± 0.8 
Fat cell weight (ng) 119 ± 14* 36 ± 5* 
Food intake (g/day) 3.28 ± 0.14 3.33 ± 0.13 
Food intake (g/day/g0.750.29 ± 0.01 0.29 ± 0.01 
Energy expenditure, EE (W/kg0.756.68 ± 0.25 7.11 ± 0.18 
Locomotor activity (counts/14 min) 2,589 ± 544 2,560 ± 499 

Values are mean ± SEM (n = 5 per group). *, P < 0.05 versus controls.

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