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TABLE I

Voltage Activation Parameters of KCNQ1 Channels in the Presence of Barium



Slope

V50

 
mV
 
mV
 
Control 16.6 ± 0.6 −26.0 ± 0.6 (18) 
0.2 mM Ba2+ 22.1 ± 2.5 −22.6 ± 1.8 (6) 
0.5 mM Ba2+ 18.5 ± 1.5 −12.8 ± 1.3 (8) 
1 mM Ba2+ 15.4 ± 1.3  −5.0 ± 1.4 (8) 
2 mM Ba2+ 16.3 ± 1.2  −3.2 ± 1.3 (7) 
4 mM Ba2+ 15.2 ± 1.3  1.5 ± 1.7 (6) 
10 mM Ba2+
 
13.9 ± 0.8
 
8.0 ± 1.3 (7)
 


Slope

V50

 
mV
 
mV
 
Control 16.6 ± 0.6 −26.0 ± 0.6 (18) 
0.2 mM Ba2+ 22.1 ± 2.5 −22.6 ± 1.8 (6) 
0.5 mM Ba2+ 18.5 ± 1.5 −12.8 ± 1.3 (8) 
1 mM Ba2+ 15.4 ± 1.3  −5.0 ± 1.4 (8) 
2 mM Ba2+ 16.3 ± 1.2  −3.2 ± 1.3 (7) 
4 mM Ba2+ 15.2 ± 1.3  1.5 ± 1.7 (6) 
10 mM Ba2+
 
13.9 ± 0.8
 
8.0 ± 1.3 (7)
 

KCNQ1 channels were exposed to the indicated external Ba2+ concentrations until reaching steady-state and then the G-V curves were constructed from the tail currents, normalized, and fitted by a Boltzmann function. The numbers in parentheses represent the number of cells.

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