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TABLE I

Inhibition of TRPM7 by Mg·ATP and Free Mg2+


Nucleotide

IC50 (μM free Mg2+)

[Free Mg2+]

IC50 (mM Mg·ATP)
None 720 ± 79 (n = 6–10) 210 μM 3.33 ± 0.49 (n = 5–12) 
1 mM MgATP 457 ± 206 (n = 5–15) 790 μM 2.0 ± 0.76 (n = 4–7) 
2 mM MgATP 256 ± 66 (n = 5) 1600 μM 1.62 ± 0.18 (n = 5–7) 
4 mM MgATP 110 ± 7 (n = 4–8)   
6 mM MgATP
 
128 ± 18 (n = 4–8)
 

 

 

Nucleotide

IC50 (μM free Mg2+)

[Free Mg2+]

IC50 (mM Mg·ATP)
None 720 ± 79 (n = 6–10) 210 μM 3.33 ± 0.49 (n = 5–12) 
1 mM MgATP 457 ± 206 (n = 5–15) 790 μM 2.0 ± 0.76 (n = 4–7) 
2 mM MgATP 256 ± 66 (n = 5) 1600 μM 1.62 ± 0.18 (n = 5–7) 
4 mM MgATP 110 ± 7 (n = 4–8)   
6 mM MgATP
 
128 ± 18 (n = 4–8)
 

 

 

Comparison of half maximal inhibitory concentrations (IC50) of free Mg2+ at fixed Mg·ATP concentrations (left two columns) and IC50 values of Mg·ATP at fixed free Mg2+ concentrations (right two columns). The whole-cell currents were recorded in HEK-293 cells induced to overexpress human TRPM7.

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