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TABLE II

Inhibition of TRPM7 by Di- and Triphosphate Nucleotides


Nucleotide

IC50 (μM)

Nucleotide

IC50 (μM)
ATP 128 ± 18 (n = 4–8) ADP 249 ± 81 (5–6) 
GTP 342 ± 95 (n = 5–12) GDP 479 ± 96 (n = 5–8) 
ITP 758 ± 60 (n = 5–19) IDP 187 ± 73 (n = 5–8) 
CTP 278 ± 103 (n = 5–11) CDP 874 ± 309 (n = 5–6) 
TTP 175 ± 42 (n = 4–8) TDP 466 ± 89 (n = 6–15) 
UTP 375 ± 25 (n = 5–10) UDP 655 ± 76 (n = 6–7) 
None
 
720 ± 79 (n = 6–10)
 

 

 

Nucleotide

IC50 (μM)

Nucleotide

IC50 (μM)
ATP 128 ± 18 (n = 4–8) ADP 249 ± 81 (5–6) 
GTP 342 ± 95 (n = 5–12) GDP 479 ± 96 (n = 5–8) 
ITP 758 ± 60 (n = 5–19) IDP 187 ± 73 (n = 5–8) 
CTP 278 ± 103 (n = 5–11) CDP 874 ± 309 (n = 5–6) 
TTP 175 ± 42 (n = 4–8) TDP 466 ± 89 (n = 6–15) 
UTP 375 ± 25 (n = 5–10) UDP 655 ± 76 (n = 6–7) 
None
 
720 ± 79 (n = 6–10)
 

 

 

Comparison of half maximal inhibitory concentrations (IC50) of free Mg2+ at fixed 6 mM NTP and NDP. The whole-cell currents were recorded in HEK-293 cells induced to overexpress human TRPM7.

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