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TABLE II

70-state Model Gating Parameters (Horrigan and Aldrich, 2002)



C–O equilibrium constant (unliganded channel, resting voltage sensors) 
 L = L0exp(zLV/kT) 
 L0 and zL, the zero voltage value of L and its partial charge, respectively 
R–A equilibrium constant (closed, unliganded channel) 
 J = J0exp(−zJV/kT) 
 J0 and zJ, the zero voltage value of J and its partial charge, respectively 
Equilibrium constant for Ca2+ binding (closed channel, resting
 voltage sensors) 
 K = [Ca2+]/Kc 
 Kc, calcium dissociation constant (closed channel, resting voltage sensors) 
Allosteric factor describing interaction between channel opening and
 Ca2+ binding 
 C = Kc/Ko 
 Ko, calcium dissociation constant (open channel, resting voltage sensors) 
Allosteric factor describing interaction between channel opening and
 voltage sensor activation 
 D = exp[−zJ(Vho − Vhc)/kT] 
 Vho and Vhc, half-activating voltage of Qc and Qo, respectively. 
 Qc and Qo, steady-state gating charge distribution for closed or open
 channels 
E
 
Allosteric factor describing interaction between Ca2+ binding and voltage
 sensor activation
 


C–O equilibrium constant (unliganded channel, resting voltage sensors) 
 L = L0exp(zLV/kT) 
 L0 and zL, the zero voltage value of L and its partial charge, respectively 
R–A equilibrium constant (closed, unliganded channel) 
 J = J0exp(−zJV/kT) 
 J0 and zJ, the zero voltage value of J and its partial charge, respectively 
Equilibrium constant for Ca2+ binding (closed channel, resting
 voltage sensors) 
 K = [Ca2+]/Kc 
 Kc, calcium dissociation constant (closed channel, resting voltage sensors) 
Allosteric factor describing interaction between channel opening and
 Ca2+ binding 
 C = Kc/Ko 
 Ko, calcium dissociation constant (open channel, resting voltage sensors) 
Allosteric factor describing interaction between channel opening and
 voltage sensor activation 
 D = exp[−zJ(Vho − Vhc)/kT] 
 Vho and Vhc, half-activating voltage of Qc and Qo, respectively. 
 Qc and Qo, steady-state gating charge distribution for closed or open
 channels 
E
 
Allosteric factor describing interaction between Ca2+ binding and voltage
 sensor activation
 
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