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Table 1.
Structures of mAChRs
ReceptorLigandLigand typeProtein Data Bank accession numberResolution (Å)Reference
M1R-T4L Tiotropium Inverse agonist 5CXV 2.7 Thal et al., 2016  
M2R-T4L QNB Inverse agonist 3UON 3.0 Haga et al., 2012  
M2R•Nb9.8 Iperoxo Agonist 4MQS 3.5 Kruse et al., 2013  
M2R•Nb9.8 Iperoxo + LY2119620 Agonist + PAM 4MQT 3.7 Kruse et al., 2013  
M3R-T4L Tiotropium Inverse agonist 4DAJ 3.4 Kruse et al., 2012  
M3R-dsT4L Tiotropium Inverse agonist 4U14 3.6 Thorsen et al., 2014  
M3R-mT4L Tiotropium Inverse agonist 4U15 2.8 Thorsen et al., 2014  
M3R-mT4L NMS Inverse agonist 4U16 3.7 Thorsen et al., 2014  
M4R-mT4L Tiotropium Inverse agonist 5DSG 2.6 Thal et al., 2016  
ReceptorLigandLigand typeProtein Data Bank accession numberResolution (Å)Reference
M1R-T4L Tiotropium Inverse agonist 5CXV 2.7 Thal et al., 2016  
M2R-T4L QNB Inverse agonist 3UON 3.0 Haga et al., 2012  
M2R•Nb9.8 Iperoxo Agonist 4MQS 3.5 Kruse et al., 2013  
M2R•Nb9.8 Iperoxo + LY2119620 Agonist + PAM 4MQT 3.7 Kruse et al., 2013  
M3R-T4L Tiotropium Inverse agonist 4DAJ 3.4 Kruse et al., 2012  
M3R-dsT4L Tiotropium Inverse agonist 4U14 3.6 Thorsen et al., 2014  
M3R-mT4L Tiotropium Inverse agonist 4U15 2.8 Thorsen et al., 2014  
M3R-mT4L NMS Inverse agonist 4U16 3.7 Thorsen et al., 2014  
M4R-mT4L Tiotropium Inverse agonist 5DSG 2.6 Thal et al., 2016  
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