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Table I

Inhibition of Agrin–induced Clustering by a Tyrphostin

TreatmentCells with more than five AChR-containing clustersInhibition
No inhibitor100 μM RG50864
None  0.6 ± 0.2%  —  — 
(five cultures)       
6 nM Laminin  1.9 ± 1.1%  —  — 
(four cultures)       
1/200 Agrin  96%  57%  40.6% 
1/200 Agrin  94%  21%  77.7% 
1/1000 Agrin  55%   8%  85.5% 
TreatmentCells with more than five AChR-containing clustersInhibition
No inhibitor100 μM RG50864
None  0.6 ± 0.2%  —  — 
(five cultures)       
6 nM Laminin  1.9 ± 1.1%  —  — 
(four cultures)       
1/200 Agrin  96%  57%  40.6% 
1/200 Agrin  94%  21%  77.7% 
1/1000 Agrin  55%   8%  85.5% 

The treatments with laminin and agrin were for 1 d. At least 100 muscle cells were assessed in each culture. All AChR-containing clusters were counted, independent of their size.  

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