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Table I

Morphometric Analysis of Presynaptic Terminals of Cultured Hippocampal Neurons before and after Hypertonic Stimulation

Numbers of Synaptic Vesicles per Unit Area in Presynaptic Terminals
Wild-typeSynapsin I−/
ExcitatoryInhibitoryExcitoryInhibitory
Control  233 ± 15 (n = 10)  209 ± 60 (n = 14)  225 ± 31 (n = 12)  245 ± 47 (n = 10) 
Stimulated  202 ± 29 (n = 12)  176 ± 27 (n = 12)  209 ± 20 (n = 8)  139 ± 25* (n = 10) 
         
  Numbers of Synaptic Vesicles per Unit Area within 200 nm from the Synaptic Cleft 
  Wild-type  Synapsin I−/ 
  Excitatory  Inhibitory  Excitatory  Inhibitory 
Control  341 ± 66 (n = 10)  270 ± 76 (n = 14)  310 ± 46 (n = 12)  335 ± 28 (n = 10) 
Stimulated  283 ± 45 (n = 12)  259 ± 30 (n = 12)  269 ± 50 (n = 8)  304 ± 72 (n = 10) 
Numbers of Synaptic Vesicles per Unit Area in Presynaptic Terminals
Wild-typeSynapsin I−/
ExcitatoryInhibitoryExcitoryInhibitory
Control  233 ± 15 (n = 10)  209 ± 60 (n = 14)  225 ± 31 (n = 12)  245 ± 47 (n = 10) 
Stimulated  202 ± 29 (n = 12)  176 ± 27 (n = 12)  209 ± 20 (n = 8)  139 ± 25* (n = 10) 
         
  Numbers of Synaptic Vesicles per Unit Area within 200 nm from the Synaptic Cleft 
  Wild-type  Synapsin I−/ 
  Excitatory  Inhibitory  Excitatory  Inhibitory 
Control  341 ± 66 (n = 10)  270 ± 76 (n = 14)  310 ± 46 (n = 12)  335 ± 28 (n = 10) 
Stimulated  283 ± 45 (n = 12)  259 ± 30 (n = 12)  269 ± 50 (n = 8)  304 ± 72 (n = 10) 
*

 Different from the value for wild-type at P < 0.05. The mean ± SD of the number of synaptic vesicles/μm2 (n represents the number of synapses examined) is shown. t test was used to determine the significance of the changes.  

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