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Table 6

Effect of tau and map1b Mutation on Neurite Development in Cultured Hippocampal Neurons

Neurite lengthNo. of neuritesn
AxonMinor process
 μm   
tau+/+map1b+/+ 172.5 ± 10.8 37.8 ± 2.7 6.2 ± 0.1 
tau−/−map1b+/+ 167.5 ± 9.9 36.9 ± 2.3 6.0 ± 0.1 
tau+/+map1b−/− 135.8 ± 4.4 25.2 ± 1.5 5.3 ± 0.4 
tau−/−map1b−/− 62.6 ± 8.0 22.0 ± 0.9 5.7 ± 0.4 
Neurite lengthNo. of neuritesn
AxonMinor process
 μm   
tau+/+map1b+/+ 172.5 ± 10.8 37.8 ± 2.7 6.2 ± 0.1 
tau−/−map1b+/+ 167.5 ± 9.9 36.9 ± 2.3 6.0 ± 0.1 
tau+/+map1b−/− 135.8 ± 4.4 25.2 ± 1.5 5.3 ± 0.4 
tau−/−map1b−/− 62.6 ± 8.0 22.0 ± 0.9 5.7 ± 0.4 

Values in each hippocampal neuron were measured directly on immunofluorescence micrographs of the cells stained using a monoclonal antibody against tubulin. n, Number of animals examined. 30 cells in stage 3 per animal were analyzed. The means ± SEM are shown.

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