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Table I.

Autotaxin/lysoPLD and family members


Enzyme

Other names

Proposed biological roles

Expression
ATX/lysoPLD NPP2, PD-1α Tumor cell motility, metastasisa, angiogenesisb, myelinationc Nearly ubiquitous (not in liver and thymus);
 up-regulated by BMP-2, bFGFb, retinoic acidd, and Wnt-1 signalingd; down-regulated by interferon-γ 
PC-1 NPP1 Bone calcification Nearly ubiquitous (not in lung and ovary) 
gp130RB13-6
 
NPP3, PD-1β, B10
 
Glial differentiation,
 cell motility/invasione
 
Nearly ubiquitous (not in heart, lung and ovary)
 

Enzyme

Other names

Proposed biological roles

Expression
ATX/lysoPLD NPP2, PD-1α Tumor cell motility, metastasisa, angiogenesisb, myelinationc Nearly ubiquitous (not in liver and thymus);
 up-regulated by BMP-2, bFGFb, retinoic acidd, and Wnt-1 signalingd; down-regulated by interferon-γ 
PC-1 NPP1 Bone calcification Nearly ubiquitous (not in lung and ovary) 
gp130RB13-6
 
NPP3, PD-1β, B10
 
Glial differentiation,
 cell motility/invasione
 
Nearly ubiquitous (not in heart, lung and ovary)
 
a

Nam et al. (2000).

b

Nam et al. (2001).

c

Fuss et al. (1997).

d

Tice et al. (2002).

e

Deissler et al. (1999).

For review and primary references see Stracke et al. (1997), Goding et al. (1998), and Bollen et al. (2000). Two putative new members, NPP4 and NPP5 (Bollen et al. 2000), are not included.

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