Rockefeller University Press

Table I.

Autotaxin/lysoPLD and family members

Enzyme	Other names	Proposed biological roles	Expression
ATX/lysoPLD	NPP2, PD-1α	Tumor cell motility, metastasis^{^a}, angiogenesis^{^b}, myelination^{^c}	Nearly ubiquitous (not in liver and thymus);  up-regulated by BMP-2, bFGF^{^b}, retinoic acid^{^d}, and Wnt-1 signaling^{^d}; down-regulated by interferon-γ
PC-1	NPP1	Bone calcification	Nearly ubiquitous (not in lung and ovary)
gp130^RB13-6	NPP3, PD-1β, B10	Glial differentiation,  cell motility/invasion^{^e}	Nearly ubiquitous (not in heart, lung and ovary)

Enzyme	Other names	Proposed biological roles	Expression
ATX/lysoPLD	NPP2, PD-1α	Tumor cell motility, metastasis^{^a}, angiogenesis^{^b}, myelination^{^c}	Nearly ubiquitous (not in liver and thymus);  up-regulated by BMP-2, bFGF^{^b}, retinoic acid^{^d}, and Wnt-1 signaling^{^d}; down-regulated by interferon-γ
PC-1	NPP1	Bone calcification	Nearly ubiquitous (not in lung and ovary)
gp130^RB13-6	NPP3, PD-1β, B10	Glial differentiation,  cell motility/invasion^{^e}	Nearly ubiquitous (not in heart, lung and ovary)

Nam et al. (2000).

Nam et al. (2001).

Fuss et al. (1997).

Tice et al. (2002).

Deissler et al. (1999).

For review and primary references see Stracke et al. (1997), Goding et al. (1998), and Bollen et al. (2000). Two putative new members, NPP4 and NPP5 (Bollen et al. 2000), are not included.

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