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Table I.

Proximal cells are more resistant to the differentiation-inducing effects of TGF-β than cells from the remaining regions of ducts


Region

Colony type

Control
 mean ± SDa

+ TGF-β
 mean ± SDa

Fold increase

Fold decrease

p-value
Proximal Basal 71.2 ± 12.6 35.9 ± 18.9  2.0 <0.001 
 Luminal 19.7 ± 10.5 41.2 ± 15.6 2.1  <0.002 
 Intermediatea 9.3 ± 7.8 23.1 ± 11.9 2.5  <0.003 
Remaining Basal 61.0 ± 26.0 7.6 ± 7.9  8.0 <0.0001 
 Luminal 33.0 ± 25.9 73.9 ± 14.8 2.2  <0.001 

 
Intermediatea
 
6.1 ± 8.3
 
18.6 ± 10.1
 
3.0
 

 
<0.02
 

Region

Colony type

Control
 mean ± SDa

+ TGF-β
 mean ± SDa

Fold increase

Fold decrease

p-value
Proximal Basal 71.2 ± 12.6 35.9 ± 18.9  2.0 <0.001 
 Luminal 19.7 ± 10.5 41.2 ± 15.6 2.1  <0.002 
 Intermediatea 9.3 ± 7.8 23.1 ± 11.9 2.5  <0.003 
Remaining Basal 61.0 ± 26.0 7.6 ± 7.9  8.0 <0.0001 
 Luminal 33.0 ± 25.9 73.9 ± 14.8 2.2  <0.001 

 
Intermediatea
 
6.1 ± 8.3
 
18.6 ± 10.1
 
3.0
 

 
<0.02
 
a

Colony type as a percentage of total colonies.

This table and Table II represent a different statistical analysis of the same data set. The data compare the types of colonies in each region in the presence and absence of TGF-β.

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