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Table II.

Proximal cells form more basal colonies and fewer luminal colonies than cells from the remaining regions of ducts after TGF-β addition


Colony type

Prox + TGF-β
 mean ± SDa

Rem + TGF-β
 mean ± SDa

Fold increase

Fold decrease

p-value
Basal 35.9 ± 18.9 7.6 ± 7.9  4.7 <0.001 
Luminal 41.2 ± 15.6 73.9 ± 14.8 1.8  <0.0001 
Intermediateb
 
23.1 ± 11.9
 
18.6 ± 10.1
 

 
1.2
 
NS
 

Colony type

Prox + TGF-β
 mean ± SDa

Rem + TGF-β
 mean ± SDa

Fold increase

Fold decrease

p-value
Basal 35.9 ± 18.9 7.6 ± 7.9  4.7 <0.001 
Luminal 41.2 ± 15.6 73.9 ± 14.8 1.8  <0.0001 
Intermediateb
 
23.1 ± 11.9
 
18.6 ± 10.1
 

 
1.2
 
NS
 
a

Colony type as a percentage of total colonies.

b

Intermediate colonies contained cells that expressed both basal and luminal cytokeratins.

This table and Table I represent a different statistical analysis of the same data set. The data compare the incidence of basal, luminal, and intermediate colonies from each region in the presence of TGF-β.

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