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Table II.

Vascular morphogenesis in P-Sp explants



Frequency
Phenotype
 Tstarta Tobserved
Controlbn (%)
Mutant
 n (%)
Sprout → growthc 58 (56.3) 40 (35.1) 
Sprout → no change 14 (13.6) 15 (13.2) 
Sprout → regressiond 31 (30.1) 59 (51.8) 
Subtotal 103 (100) 114 (100) 
Network → growthe 39 (45.9) 22 (23.9) 
Network → no change 30 (35.3) 23 (25.0) 
Network → regressiond 16 (18.8) 47 (51.1) 
Subtotal
 
85 (100) 92 (100) 


Frequency
Phenotype
 Tstarta Tobserved
Controlbn (%)
Mutant
 n (%)
Sprout → growthc 58 (56.3) 40 (35.1) 
Sprout → no change 14 (13.6) 15 (13.2) 
Sprout → regressiond 31 (30.1) 59 (51.8) 
Subtotal 103 (100) 114 (100) 
Network → growthe 39 (45.9) 22 (23.9) 
Network → no change 30 (35.3) 23 (25.0) 
Network → regressiond 16 (18.8) 47 (51.1) 
Subtotal
 
85 (100) 92 (100) 
a

The subcategories were defined as the phenotype at the initial point of time-lapse videos (Tstart). The videos were captured at 10-min intervals for 24–48 h.

b

Controls: Tie2-Cre;fakflox/+ or fakflox/+; mutants: Tie2-Cre;fakflox/flox.

c

Elongation, widening, and network formation from sprouts.

d

Reduction in length or size and degeneration, including cell death.

e

Increased network complexity and caliber.

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