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Table I.

Genes regulated by JunB and hypoxia in ECs

Gene
Gene name
Unigene No.
JunB
Hx
Function
Mospd1 motile sperm domain containing 1 Mm.28236 6.5 2.9 Cytoskeleton 
Cbfb core binding factor beta Mm.2018 6.5 2.0 Transcription 
Cnot6l CCR4-NOT transcription compl. subunit 6-like Mm.28374 6.1 2.6 Transcription 
Wdr26 WD repeat domain 26 Mm.289082 4.6 4.1 Signaling 
Acsl4 acyl-CoA synthetase long chain family 4 Mm.143689 4.2 3.1 Metabolism 
Rbmxrt RNA binding motif protein, X chromosome Mm.24718 3.6 5.0 Apoptosis 
D530031C13Rik RIKEN cDNA D530031C13 gene Mm.390454 3.5 3.9 unknown 
Ubp1 (LBP-1a) upstream binding protein 1 Mm.28052 3.5 2.6 Transcription 
Tpt1 tumor protein translationally controlled 1 Mm.296922 3.3 3.2 Signaling 
Eif3s10 eukar. translation initiation factor 3, subunit 10 Mm.2238 3.2 2.3 Translation 
Ncald neurocalcin delta Mm.283370 2.9 4.6 Signaling 
Creb3l2 CRE-binding protein 3-like 2 Mm.169929 2.9 4.2 Transcription 
Top2b topoisomerase II beta Mm.130362 2.9 2.3 Transcription 
Phf17 PHD finger protein 17 Mm.286285 2.8 14.0 Transcription 
Rhpn2 rhophilin-2 Mm.286600 2.5 2.9 Cytoskeleton 
Nes nestin Mm.331129 2.5 2.5 Cytoskeleton 
Scmh1 sex comb on midleg homologue 1 Mm.208924 2.4 3.8 Differentiation 
Tram1 translocating chain-assoc. membrane protein 1 Mm.28765 2.4 2.1 Transport 
AI848100 expressed sequence AI848100 Mm.170002 2.4 3.2 unknown 
Arid2 AT rich interactive domain 2 Mm.17166 2.3 2.3 Transcription 
Bnip3l (Nix) BCL2/adenovirus E1B interacting protein 3-like Mm.29820 2.2 2.4 Apoptosis 
Kif5b kinesin family member 5B Mm.223744 2.2 4.5 Transport 
Btbd1 BTB domain containing 1 Mm.71103 2.1 3.7 Differentiation 
Tbcd tubulin-specific chaperone d Mm.23686 −11.2 −2.2 Cytoskeleton 
2810428I15Rik RIKEN cDNA 2810428I15 gene Mm.28242 −7.7 −3.0 unknown 
Diablo diablo homologue (smac) Mm.46716 −6.1 −2.5 Apoptosis 
Myo 1D myosin 1 D Mm.151948 −5.9 −2.6 Transport 
Pou6f1 POU domain, class 6, transcription factor 1 Mm.28825 −5.3 −4.0 Transcription 
Aldh1b1 aldehyde dehydrogenase 1 family member B1 Mm.331583 −4.5 −29.8 Metabolism 
Klf16 kruppel-like factor 16 Mm.41513 −4.4 −3.3 Transcription 
3200001K10Rik RIKEN cDNA 3200001K10 gene Mm.304075 −4.2 −2.5 unknown 
FoxJ2 forkhead box J2 Mm.87142 −3.9 −4.7 Transcription 
2900070E19Rik RIKEN cDNA 2900070E19 gene Mm.29128 −3.0 −2.2 unknown 
Tgm2 transglutaminase 2, c polypeptide Mm.330731 −3.0 −2.4 Metabolism 
Fdft1 farnesyl diphosphate farnesyl transferase 1 Mm.343538 −2.8 −2.8 Metabolism 
Farsla phenylalanine-tRNA synthetase-like, alpha subunit Mm.292517 −2.6 −2.1 Translation 
6720457D02Rik RIKEN cDNA 6720457D02 gene Mm.102840 −2.3 −7.4 unknown 
Aars alanyl-tRNA synthetase Mm.24174 −2.1 −4.0 Translation 
Gspt1 G1 to S phase transition 1 Mm.325827 −2.1 −2.8 Translation 
Gene
Gene name
Unigene No.
JunB
Hx
Function
Mospd1 motile sperm domain containing 1 Mm.28236 6.5 2.9 Cytoskeleton 
Cbfb core binding factor beta Mm.2018 6.5 2.0 Transcription 
Cnot6l CCR4-NOT transcription compl. subunit 6-like Mm.28374 6.1 2.6 Transcription 
Wdr26 WD repeat domain 26 Mm.289082 4.6 4.1 Signaling 
Acsl4 acyl-CoA synthetase long chain family 4 Mm.143689 4.2 3.1 Metabolism 
Rbmxrt RNA binding motif protein, X chromosome Mm.24718 3.6 5.0 Apoptosis 
D530031C13Rik RIKEN cDNA D530031C13 gene Mm.390454 3.5 3.9 unknown 
Ubp1 (LBP-1a) upstream binding protein 1 Mm.28052 3.5 2.6 Transcription 
Tpt1 tumor protein translationally controlled 1 Mm.296922 3.3 3.2 Signaling 
Eif3s10 eukar. translation initiation factor 3, subunit 10 Mm.2238 3.2 2.3 Translation 
Ncald neurocalcin delta Mm.283370 2.9 4.6 Signaling 
Creb3l2 CRE-binding protein 3-like 2 Mm.169929 2.9 4.2 Transcription 
Top2b topoisomerase II beta Mm.130362 2.9 2.3 Transcription 
Phf17 PHD finger protein 17 Mm.286285 2.8 14.0 Transcription 
Rhpn2 rhophilin-2 Mm.286600 2.5 2.9 Cytoskeleton 
Nes nestin Mm.331129 2.5 2.5 Cytoskeleton 
Scmh1 sex comb on midleg homologue 1 Mm.208924 2.4 3.8 Differentiation 
Tram1 translocating chain-assoc. membrane protein 1 Mm.28765 2.4 2.1 Transport 
AI848100 expressed sequence AI848100 Mm.170002 2.4 3.2 unknown 
Arid2 AT rich interactive domain 2 Mm.17166 2.3 2.3 Transcription 
Bnip3l (Nix) BCL2/adenovirus E1B interacting protein 3-like Mm.29820 2.2 2.4 Apoptosis 
Kif5b kinesin family member 5B Mm.223744 2.2 4.5 Transport 
Btbd1 BTB domain containing 1 Mm.71103 2.1 3.7 Differentiation 
Tbcd tubulin-specific chaperone d Mm.23686 −11.2 −2.2 Cytoskeleton 
2810428I15Rik RIKEN cDNA 2810428I15 gene Mm.28242 −7.7 −3.0 unknown 
Diablo diablo homologue (smac) Mm.46716 −6.1 −2.5 Apoptosis 
Myo 1D myosin 1 D Mm.151948 −5.9 −2.6 Transport 
Pou6f1 POU domain, class 6, transcription factor 1 Mm.28825 −5.3 −4.0 Transcription 
Aldh1b1 aldehyde dehydrogenase 1 family member B1 Mm.331583 −4.5 −29.8 Metabolism 
Klf16 kruppel-like factor 16 Mm.41513 −4.4 −3.3 Transcription 
3200001K10Rik RIKEN cDNA 3200001K10 gene Mm.304075 −4.2 −2.5 unknown 
FoxJ2 forkhead box J2 Mm.87142 −3.9 −4.7 Transcription 
2900070E19Rik RIKEN cDNA 2900070E19 gene Mm.29128 −3.0 −2.2 unknown 
Tgm2 transglutaminase 2, c polypeptide Mm.330731 −3.0 −2.4 Metabolism 
Fdft1 farnesyl diphosphate farnesyl transferase 1 Mm.343538 −2.8 −2.8 Metabolism 
Farsla phenylalanine-tRNA synthetase-like, alpha subunit Mm.292517 −2.6 −2.1 Translation 
6720457D02Rik RIKEN cDNA 6720457D02 gene Mm.102840 −2.3 −7.4 unknown 
Aars alanyl-tRNA synthetase Mm.24174 −2.1 −4.0 Translation 
Gspt1 G1 to S phase transition 1 Mm.325827 −2.1 −2.8 Translation 

Control and JunB-deficient END cells were kept under normoxic or hypoxic conditions for 16 h, and total RNA was isolated and subjected to microarray analysis. The table lists identified genes differentially regulated by JunB and hypoxia. JunB, fold induction of genes in control versus JunB-deficient END cells; Hx, fold induction of genes kept under hypoxia (1.5% O2) versus normoxia. All genes listed from Tbcd downward are repressed genes.

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