Offspring analysis of p14−/− mice
| Age of crosses . | p14+/+ . | p14−/+ . | p14−/− . | p14f/− . | p14f/+ . |
|---|---|---|---|---|---|
| p14−/+ × p14−/+ | |||||
| E6.5 (n = 29) | 6 | 15 | 8 | ND | ND |
| E8.5 (n = 50) | 13 | 25 | 12 | ND | ND |
| E10.5 (n = 70) | 19 | 51 | 0 | ND | ND |
| PN21 (n = 210) | 70 | 140 | 0 | ND | ND |
| p14−/f × p14−/+;MORE | |||||
| E10.5 (n = 30) | ND | 13 | 0 | 7 | 10 |
| PN21 (n = 56) | 0 | 20 | 0 | 17 | 19 |
| Age of crosses . | p14+/+ . | p14−/+ . | p14−/− . | p14f/− . | p14f/+ . |
|---|---|---|---|---|---|
| p14−/+ × p14−/+ | |||||
| E6.5 (n = 29) | 6 | 15 | 8 | ND | ND |
| E8.5 (n = 50) | 13 | 25 | 12 | ND | ND |
| E10.5 (n = 70) | 19 | 51 | 0 | ND | ND |
| PN21 (n = 210) | 70 | 140 | 0 | ND | ND |
| p14−/f × p14−/+;MORE | |||||
| E10.5 (n = 30) | ND | 13 | 0 | 7 | 10 |
| PN21 (n = 56) | 0 | 20 | 0 | 17 | 19 |
p14−/+ intercrosses were analyzed at different developmental stages. Before E6.5, no phenotypic abnormalities of the embryos could be detected. Upon E10.5, no p14−/− embryos could be detected. The epiblast-restricted deletion of p14 caused the embryonic lethality of p14−/− mice resulting from p14−/f × p14−/+;MORE crosses. The numbers of embryos at the indicated developmental stages are given. PN, postnatal.