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Table I.

Inhibition of myosin II activity reduces the amount of Ag and MHC class II molecules that concentrate together in lysosomes


Ag
MHC II
Ratio of
 Ag/MHC II
DMSO-treated cells 200 663 0.302 
ML-7/Y27632-
     treated cells 28 288 0.123 

Ag
MHC II
Ratio of
 Ag/MHC II
DMSO-treated cells 200 663 0.302 
ML-7/Y27632-
     treated cells 28 288 0.123 

Quantification of the immunogold cryoelectron microscopy experiments shown in Fig. 5. Gold particles from 30 compartments were counted in randomly selected B cell profiles. We could estimate that the compartments presenting vacuolar empty morphology in drug-treated cells represent ∼70% of the total compartments observed. No vacuolar compartment was observed in nontreated cells.

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