Sm proteins bind to snRNPs and become concentrated in CBs. FLICE-associated huge protein (FLASH) has recently been described as a component of CBs (Barcaroli et al., 2006). PML is the major component of the nuclear bodies, which are called PML nuclear bodies, ND10, or PML oncogenic domains. PML is degraded in an ICP0- and proteasomal-dependent manner (Everett et al., 1998). Under certain circumstances, PML bodies can be connected to centromeres in the G2 phase (Everett et al., 1999b; Luciani et al., 2006). PA28γ (proteasome activator γ) has recently been shown to colocalize and associate with coilin in UV-C–treated cells (Cioce et al., 2006).

As shown by immuno-RNA FISH assays (see Fig. 3 b, ii).

As detected by the 5′-2,2,7-trimethylguanosine (TMG) antibody, which recognizes TMG-capped snRNAs.