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Table 1.
Regulators of the RAG GTPases involved in mediating amino acid signaling to mTORC1
Yeast orthologuesMammalian orthologuesComponentFunctionmTORC1 activationReferences
EGO complex (Ego1-Ego2-Ego3); VAM6 Ragulator LAMTOR1 (p18), LAMTOR2 (p14), LAMTOR3 (MP1), LAMTOR4 (C7orf59), LAMTOR5 (HBXIP) GEF for Rag-A/B; tethers the Rags to the lysosome Up Binda et al., 2009; Nada et al., 2009; Sancak et al., 2010; Bar-Peled et al., 2012; Powis et al., 2015  
SEACIT (Sea1, Npr2, Npr3) GATOR1 DEPDC5, Nprl2, Nprl3 GAP for Rag-A/B Down Dokudovskaya and Rout, 2011; Bar-Peled et al., 2013; Panchaud et al., 2013  
SEACAT (Sea4, Seh1, Sea2, Sea3, Sec13) GATOR2 Mios, Seh1L, WDR24, WDR59, Sec13 Inhibits GATOR1 Up Dokudovskaya et al., 2011; Bar-Peled et al., 2013; Panchaud et al., 2013  
Lst4/Lst7 FOLLICULIN FNIP1/2-FLCN GAP for Rag-C/D Up Petit et al., 2013; Tsun et al., 2013; Péli-Gulli et al., 2015  
 SH3BP4 SH3BP4 Inhibits Rag-A/B through direct binding Down Kim et al., 2012  
 RNF152 RNF152 Ubiquitinates (K63) RagA, promotes interaction between RagA and GATOR1 Down Deng et al., 2015  
 SKP2 SKP2 Ubiquitinates (K63) RagA, promotes interaction between RagA and GATOR1 Down Jin et al., 2015  
Yeast orthologuesMammalian orthologuesComponentFunctionmTORC1 activationReferences
EGO complex (Ego1-Ego2-Ego3); VAM6 Ragulator LAMTOR1 (p18), LAMTOR2 (p14), LAMTOR3 (MP1), LAMTOR4 (C7orf59), LAMTOR5 (HBXIP) GEF for Rag-A/B; tethers the Rags to the lysosome Up Binda et al., 2009; Nada et al., 2009; Sancak et al., 2010; Bar-Peled et al., 2012; Powis et al., 2015  
SEACIT (Sea1, Npr2, Npr3) GATOR1 DEPDC5, Nprl2, Nprl3 GAP for Rag-A/B Down Dokudovskaya and Rout, 2011; Bar-Peled et al., 2013; Panchaud et al., 2013  
SEACAT (Sea4, Seh1, Sea2, Sea3, Sec13) GATOR2 Mios, Seh1L, WDR24, WDR59, Sec13 Inhibits GATOR1 Up Dokudovskaya et al., 2011; Bar-Peled et al., 2013; Panchaud et al., 2013  
Lst4/Lst7 FOLLICULIN FNIP1/2-FLCN GAP for Rag-C/D Up Petit et al., 2013; Tsun et al., 2013; Péli-Gulli et al., 2015  
 SH3BP4 SH3BP4 Inhibits Rag-A/B through direct binding Down Kim et al., 2012  
 RNF152 RNF152 Ubiquitinates (K63) RagA, promotes interaction between RagA and GATOR1 Down Deng et al., 2015  
 SKP2 SKP2 Ubiquitinates (K63) RagA, promotes interaction between RagA and GATOR1 Down Jin et al., 2015  
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