Rockefeller University Press

Table 1.

Lamin fiber–NPC center to center distance distributions for WT, Lmnb1^−/−, and Lmna^−/− MEFs

Cell	Lamin	Observed (nm)		Expected (nm)		Observed − expected (nm)		P values		No. of NPCs
Genotype	Labeled	Median	SD	Median	SD	Median	SD	Median	SD	N
WT	LA	40.4	38.0	33.5	56.5	6.9	−18.5	0.00		14,780
WT	LC	32.8	35.0	32.1	49.4	0.7	−14.5	0.37^a	0.01^a	11,459
WT	LB1	38.1	36.2	32.1	56.9	6.0	−20.7	0.00		15,150
WT	LB2	27.6	29.2	28.1	38.7	−0.6	−9.6	0.00		17,146
Lmnb1^−/−	LA	45.1	48.6	42.4	216.8	2.7	−168.2	0.59^a	0.00	11,971
Lmna^−/−	LB1	34.9	34.5	35.8	297.7	−0.8	−263.1	0.00		9,740

Cell	Lamin	Observed (nm)		Expected (nm)		Observed − expected (nm)		P values		No. of NPCs
Genotype	Labeled	Median	SD	Median	SD	Median	SD	Median	SD	N
WT	LA	40.4	38.0	33.5	56.5	6.9	−18.5	0.00		14,780
WT	LC	32.8	35.0	32.1	49.4	0.7	−14.5	0.37^a	0.01^a	11,459
WT	LB1	38.1	36.2	32.1	56.9	6.0	−20.7	0.00		15,150
WT	LB2	27.6	29.2	28.1	38.7	−0.6	−9.6	0.00		17,146
Lmnb1^−/−	LA	45.1	48.6	42.4	216.8	2.7	−168.2	0.59^a	0.00	11,971
Lmna^−/−	LB1	34.9	34.5	35.8	297.7	−0.8	−263.1	0.00		9,740

Median and SD of the observed and expected lamin fiber to NPC center to center distances, the difference between them, P values (see Materials and methods), and number of NPCs. The data in each row were collected from 10 cells. The Mann-Whitney U test and Ansari-Bradley test were used as described in Materials and methods.

^aP values above the Bonferroni corrected α value of 0.05/8 tests = 0.006.

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