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Table 2.

Face–NPC center to center distance distributions for WT, Lmnb1^−/−, and Lmna^−/− MEFs

Cell	Lamin	Observed (nm)		Expected (nm)		Observed − expected (nm)		P values		No. of NPCs
Genotype	Labeled	Median	SD	Median	SD	Median	SD	Median	SD	N
WT	LA	119.3	62.6	130.9	78.3	−11.7	−15.7	0.00		14,780
WT	LC	122.4	57.1	125.7	69.0	−3.3	−11.9	0.00		11,459
WT	LB1	118.3	56.8	129.1	76.0	−10.8	−19.2	0.00		15,150
WT	LB2	116.7	51.5	117.3	58.9	−0.6	−7.3	0.25^a	0.08^a	17,146
Lmnb1^−/−	LA	124.0	90.0	146.0	235.2	−22.0	−145.2	0.00		11,971
Lmna^−/−	LB1	122.1	55.7	133.2	304.3	−11.1	−248.6	0.00		9,740

Cell	Lamin	Observed (nm)		Expected (nm)		Observed − expected (nm)		P values		No. of NPCs
Genotype	Labeled	Median	SD	Median	SD	Median	SD	Median	SD	N
WT	LA	119.3	62.6	130.9	78.3	−11.7	−15.7	0.00		14,780
WT	LC	122.4	57.1	125.7	69.0	−3.3	−11.9	0.00		11,459
WT	LB1	118.3	56.8	129.1	76.0	−10.8	−19.2	0.00		15,150
WT	LB2	116.7	51.5	117.3	58.9	−0.6	−7.3	0.25^a	0.08^a	17,146
Lmnb1^−/−	LA	124.0	90.0	146.0	235.2	−22.0	−145.2	0.00		11,971
Lmna^−/−	LB1	122.1	55.7	133.2	304.3	−11.1	−248.6	0.00		9,740

Median and SD of the observed and expected lamin face to NPC distances, the difference between them, P values (see Materials and methods), and number of NPCs. The data in each row were collected from 10 cells. The Mann Whitney U test and Ansari-Bradley test were used as described in Materials and methods.

^aP values above the Bonferroni corrected α value of 0.05/7 tests = 0.007.

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