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Table 1.
IL-17–driven metabolic pathways in health and disease
IL-17–mediated metabolic regulation during homeostasis
IL-17 target cellsMetabolic regulationCellular outcomeOrganismal outcomeReferences
Epithelial cells/Mesenchymal cells  Unknown Proliferation Tissue repair and wound healing Lee et al. (2015), Song et al. (2015), MacLeod et al. (2013), Chen et al. (2019), Floudas et al. (2017)  
Adipocytes Decreased expression of proadipogenic TFs Suppressed differentiation of adipocytes Decreased adipose tissue mass accumulation Ahmed and Gaffen (2013)  
 Decreased insulin-mediated glucose uptake in vitro Unknown Unknown Zúñiga et al. (2010)  
 Increased expression of thermogenic genes Enhanced metabolic respiration via uncoupled oxidative phosphorylation Thermogenesis Kohlgruber et al. (2018), Papotto and Silva-Santos (2018)  
Stromal adipose cells Unknown IL-33 production Insulin sensitivity Kohlgruber et al. (2018), Papotto and Silva-Santos (2018)  
IL-17–mediated metabolic regulation during disease 
IL-17 target cells Metabolic regulation Cellular outcome Organismal outcome References 
Epithelial cells/Mesenchymal cells Unknown ECM production Fibrosis Okamoto et al. (2012), Madhur et al. (2010), Wilson et al. (2010), Wu et al. (2014), Mi et al. (2011)  
 Increased glycolysis Proliferation Tumorigenesis Terzić et al. (2010), Straus (2013)  
Keratinocytes Reprogramming of urea cycle Proinflammatory gene expression Psoriasis Lou et al. (2020), Bandyopadhyay and Larregina (2020)  
 Increased cholesterol uptake Proinflammatory gene expression Psoriasis Varshney et al. (2016)  
SFs Decreased expression of oxidative phosphorylation genes Cell survival RA Kim et al. (2017)  
 Increased expression of amino acid transporter 1 Increased cell migratory capacity RA Yu et al. (2018)  
FRCs Increased glycolysis/Increased FAO Cell survival and proinflammatory genes expression EAE/Colitis Majumder et al. (2019)  
IL-17–mediated metabolic regulation during homeostasis
IL-17 target cellsMetabolic regulationCellular outcomeOrganismal outcomeReferences
Epithelial cells/Mesenchymal cells  Unknown Proliferation Tissue repair and wound healing Lee et al. (2015), Song et al. (2015), MacLeod et al. (2013), Chen et al. (2019), Floudas et al. (2017)  
Adipocytes Decreased expression of proadipogenic TFs Suppressed differentiation of adipocytes Decreased adipose tissue mass accumulation Ahmed and Gaffen (2013)  
 Decreased insulin-mediated glucose uptake in vitro Unknown Unknown Zúñiga et al. (2010)  
 Increased expression of thermogenic genes Enhanced metabolic respiration via uncoupled oxidative phosphorylation Thermogenesis Kohlgruber et al. (2018), Papotto and Silva-Santos (2018)  
Stromal adipose cells Unknown IL-33 production Insulin sensitivity Kohlgruber et al. (2018), Papotto and Silva-Santos (2018)  
IL-17–mediated metabolic regulation during disease 
IL-17 target cells Metabolic regulation Cellular outcome Organismal outcome References 
Epithelial cells/Mesenchymal cells Unknown ECM production Fibrosis Okamoto et al. (2012), Madhur et al. (2010), Wilson et al. (2010), Wu et al. (2014), Mi et al. (2011)  
 Increased glycolysis Proliferation Tumorigenesis Terzić et al. (2010), Straus (2013)  
Keratinocytes Reprogramming of urea cycle Proinflammatory gene expression Psoriasis Lou et al. (2020), Bandyopadhyay and Larregina (2020)  
 Increased cholesterol uptake Proinflammatory gene expression Psoriasis Varshney et al. (2016)  
SFs Decreased expression of oxidative phosphorylation genes Cell survival RA Kim et al. (2017)  
 Increased expression of amino acid transporter 1 Increased cell migratory capacity RA Yu et al. (2018)  
FRCs Increased glycolysis/Increased FAO Cell survival and proinflammatory genes expression EAE/Colitis Majumder et al. (2019)  

The metabolism-modulating activities of IL-17 are context dependent and may vary on the basis of its target cells.

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