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Table 2.
Cross-reactivity of anti-POWV mAbs against TBFVs
Competition groupmAbBinding (flow cytometry)aEC50 (ng/ml)b
TBEVLGTVGGYVTBEVLGTVGGYV
None POWV-16 ++ ++     
POWV-4 ++ ++ ++    
POWV-5       
POWV-18       
POWV-54 ++ ++ ++  1,480 7,818 
POWV-56 ++ ++ ++  11,477  
POWV-63 ++ ++ ++  2,520 11,183 
POWV-14     10,289  
POWV-15       
POWV-23       
POWV-48       
POWV-62   ++    
POWV-70   ++    
POWV-33 ++   1,615   
POWV-37 ++   587   
POWV-65       
POWV-71 ++ ++   44  
POWV-80 ++ ++  8,475 10,354  
POWV-55       
POWV-60       
POWV-61       
Competition groupmAbBinding (flow cytometry)aEC50 (ng/ml)b
TBEVLGTVGGYVTBEVLGTVGGYV
None POWV-16 ++ ++     
POWV-4 ++ ++ ++    
POWV-5       
POWV-18       
POWV-54 ++ ++ ++  1,480 7,818 
POWV-56 ++ ++ ++  11,477  
POWV-63 ++ ++ ++  2,520 11,183 
POWV-14     10,289  
POWV-15       
POWV-23       
POWV-48       
POWV-62   ++    
POWV-70   ++    
POWV-33 ++   1,615   
POWV-37 ++   587   
POWV-65       
POWV-71 ++ ++   44  
POWV-80 ++ ++  8,475 10,354  
POWV-55       
POWV-60       
POWV-61       
a

Cross-reactivity to other TBFVs was determined by mAb binding of C-prM-E–transfected cells by flow cytometry.

b

Cross-neutralization was assessed by FRNT (LGTV) or an RVP-based assay (TBEV and GGYV) in Vero cells. Geometric mean EC50 values are from two to three independent experiments.

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