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Table 1.
Comparison of oligomeric configuration with pore constriction diameter
ATP-permeant channelOligomeric configurationPore constriction diameter (Å)Reference
VDAC Monomer (β barrel) 25 Colombini, 2012  
Cx26 Hexamer 14 (open), 6 (closed) Maeda et al., 2009; Nielsen et al., 2012  
Cx31.3 Hexamer 8 (closed?) Lee et al., 2020  
Cx43 Hexamer 25 (open), 18 (closed) Nielsen et al., 2012  
Cx46 Hexamer 14 Myers et al., 2018; Flores et al., 2020  
VRAC Hexamer 12–14 (open), 2–5 (closed) Deneka et al., 2018; Kasuya et al., 2018; Kefauver et al., 2018; Osei-Owusu et al., 2018  
Panx1 Heptamer Deng et al., 2020; Jin et al., 2020; Michalski et al., 2020; Mou et al., 2020; Qu et al., 2020; Ruan et al., 2020  
Innexin6 Octamer 18 Oshima et al., 2016  
CALHM1 Octamer 19.5 Syrjanen et al., 2020  
CALHM2 Undecamer 50 (open), 23 (inhibited) Choi et al., 2019  
CALHM4 Decamer, undecamer 20 (without current), 30 (without current) Drożdżyk et al., 2020  
ATP-permeant channelOligomeric configurationPore constriction diameter (Å)Reference
VDAC Monomer (β barrel) 25 Colombini, 2012  
Cx26 Hexamer 14 (open), 6 (closed) Maeda et al., 2009; Nielsen et al., 2012  
Cx31.3 Hexamer 8 (closed?) Lee et al., 2020  
Cx43 Hexamer 25 (open), 18 (closed) Nielsen et al., 2012  
Cx46 Hexamer 14 Myers et al., 2018; Flores et al., 2020  
VRAC Hexamer 12–14 (open), 2–5 (closed) Deneka et al., 2018; Kasuya et al., 2018; Kefauver et al., 2018; Osei-Owusu et al., 2018  
Panx1 Heptamer Deng et al., 2020; Jin et al., 2020; Michalski et al., 2020; Mou et al., 2020; Qu et al., 2020; Ruan et al., 2020  
Innexin6 Octamer 18 Oshima et al., 2016  
CALHM1 Octamer 19.5 Syrjanen et al., 2020  
CALHM2 Undecamer 50 (open), 23 (inhibited) Choi et al., 2019  
CALHM4 Decamer, undecamer 20 (without current), 30 (without current) Drożdżyk et al., 2020  
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