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Table 2.
Lung histopathological analysis of NET-infiltrating area in COVID-19 patients
Patient no.1234
No. of NET-infiltrating area identified Total 17 13 14 10 
Vascular compartment 
Interstitial compartment 
Alveolar compartment 13 
Bronchial compartment 
Alveolar lesions Inflammation PMN, macrophages, fibrin, giant and atypical cells PMN, macrophages, fibrin, giant and atypical cells PMN, macrophages, fibrin, rare atypical cells PMN, macrophages, fibrin, hyaline membranes 
Hemorrhage − − 
Bronchial lesions Inflammation Intra- and peri-bronchial: PMN, macrophages; rare red blood cells and desquamative epithelial cells 
Interstitial lesions Inflammation PMN, macrophages, fibrin, giant cell, atypical cells PMN, macrophages, fibrin PMN, fibrin 
Hemorrhage − 
Fibrosis 
Vascular lesions Thrombi 
Affected vessels Arterioles Arterioles Arterioles 
Other PMN, fibrin, red blood cells Fibrin Fibrin, PMN 
Patient no.1234
No. of NET-infiltrating area identified Total 17 13 14 10 
Vascular compartment 
Interstitial compartment 
Alveolar compartment 13 
Bronchial compartment 
Alveolar lesions Inflammation PMN, macrophages, fibrin, giant and atypical cells PMN, macrophages, fibrin, giant and atypical cells PMN, macrophages, fibrin, rare atypical cells PMN, macrophages, fibrin, hyaline membranes 
Hemorrhage − − 
Bronchial lesions Inflammation Intra- and peri-bronchial: PMN, macrophages; rare red blood cells and desquamative epithelial cells 
Interstitial lesions Inflammation PMN, macrophages, fibrin, giant cell, atypical cells PMN, macrophages, fibrin PMN, fibrin 
Hemorrhage − 
Fibrosis 
Vascular lesions Thrombi 
Affected vessels Arterioles Arterioles Arterioles 
Other PMN, fibrin, red blood cells Fibrin Fibrin, PMN 

Some NET-infiltrating areas encompassed several compartments. /, not applicable (no NET detected in the indicated compartment); −, absent; +, present; PMN, polymorphonuclear leukocytes.

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