Skip to Main Content
Table 2.
Comparison of the functional effects of S6 mutations
ChannelBTXresistant?Activation shift? ΔV1/2 act(mV)Inactivation shift? ΔV1/2 inact(mV)Decrease in current density? (fold change)
Pum NaV1.4 N432T (DI) No No No No 
Pum NaV1.4 N830T (DII) No No Yes; −10.8 ± 1.6 Yes; 14.8 
Pum NaV1.4 N1306T (DIII) No No No No 
Pum NaV1.4 N1609T (DIV) Yes Yes; +20.5 ± 1.5 Yes; −10.3 ± 2.1 Yes; 4.9 
Pum NaV1.4 N1609A (DIV) No Yes; +19.6 ± 1.6 Yes; −13.4 ± 1.6 Yes; 4.1 
Hs NaV1.4 N1591T (DIV) Yes Yes; +16.9 ± 2.7 Yes; −9.8 ± 1.2 Yes; 2.2 
Rn NaV1.4 N1584T (DIV) Yes Yes; +18.0 ± 0.6 Yes; −27.0 ± 0.4 Yes; 10.3 
Pt NaV1.4 (N1600T) (DIV) No No Yes; −7.7 ± 0.9 No* 
Dt NaV1.4 (N1600T) (DIV) No No Yes; −9.8 ± 1.9 No* 
ChannelBTXresistant?Activation shift? ΔV1/2 act(mV)Inactivation shift? ΔV1/2 inact(mV)Decrease in current density? (fold change)
Pum NaV1.4 N432T (DI) No No No No 
Pum NaV1.4 N830T (DII) No No Yes; −10.8 ± 1.6 Yes; 14.8 
Pum NaV1.4 N1306T (DIII) No No No No 
Pum NaV1.4 N1609T (DIV) Yes Yes; +20.5 ± 1.5 Yes; −10.3 ± 2.1 Yes; 4.9 
Pum NaV1.4 N1609A (DIV) No Yes; +19.6 ± 1.6 Yes; −13.4 ± 1.6 Yes; 4.1 
Hs NaV1.4 N1591T (DIV) Yes Yes; +16.9 ± 2.7 Yes; −9.8 ± 1.2 Yes; 2.2 
Rn NaV1.4 N1584T (DIV) Yes Yes; +18.0 ± 0.6 Yes; −27.0 ± 0.4 Yes; 10.3 
Pt NaV1.4 (N1600T) (DIV) No No Yes; −7.7 ± 0.9 No* 
Dt NaV1.4 (N1600T) (DIV) No No Yes; −9.8 ± 1.9 No* 

Data represent measurements in transfected HEK293 cells. *, substantial current density loss in Xenopus oocytes. ΔV1/2 act = V1/2, act mutant -V1/2, act WT. ΔV1/2 inact = V1/2, inact mutant -V1/2, inact WT.

Close Modal

or Create an Account

Close Modal
Close Modal