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Table 1.
Top 30 gene signatures of each of incipient, subclinical, and clinical TB
Incipient versus controlSubclinical versus controlClinical versus control
MTRNR2L10a MSLN MTRNR2L10a 
C1QCb CCDC144A C1QCb 
C1QBa SPACA3 MTRNR2L1 
CCL2 HIST1H4A C1QBa 
HESX1 HIST1H1B ANKRD22a 
PCGF2 HIST1H4F SEPT4 
SERPING1b NXPH3 SERPING1b 
LCN8 HIST1H4B BATF2b 
SEMA6B ZBED6 FAM20A 
SIGLEC1 HSPA12B ETV7b 
C1QAa TRAJ4 EXOC3L4 
ISG15 ETV7b PDCD1LG2 
AHRR TAS2R3 METTL7B 
NEIL3 HTRA1 APOL4 
FBXO39 BATF2b CFB 
AXL SERPING1b C1QAa 
C2a GALNT4 VWA3B 
IFI6 HIST2H2AB SLC8A2 
LGALS2 HIST1H1D GBP6a 
IFITM3 HIST1H1E FCGR1A 
RUFY4 GBP6a C2a 
ETV7b HIST1H3C CARD17 
TCN2 SLC2A14 EXOC3L1a 
LGALS3BP TICAM2 RHOV 
EXOC3L1a GBP5 AOC1 
COL23A1 C1QCb KCNMA1 
MT2A TAS2R60 FAM26F 
BATF2b ANKRD22a KCNJ10 
CXCL10 CH17-296N19.1 CD274 
SCT HIST1H4C SDC3 
Incipient versus controlSubclinical versus controlClinical versus control
MTRNR2L10a MSLN MTRNR2L10a 
C1QCb CCDC144A C1QCb 
C1QBa SPACA3 MTRNR2L1 
CCL2 HIST1H4A C1QBa 
HESX1 HIST1H1B ANKRD22a 
PCGF2 HIST1H4F SEPT4 
SERPING1b NXPH3 SERPING1b 
LCN8 HIST1H4B BATF2b 
SEMA6B ZBED6 FAM20A 
SIGLEC1 HSPA12B ETV7b 
C1QAa TRAJ4 EXOC3L4 
ISG15 ETV7b PDCD1LG2 
AHRR TAS2R3 METTL7B 
NEIL3 HTRA1 APOL4 
FBXO39 BATF2b CFB 
AXL SERPING1b C1QAa 
C2a GALNT4 VWA3B 
IFI6 HIST2H2AB SLC8A2 
LGALS2 HIST1H1D GBP6a 
IFITM3 HIST1H1E FCGR1A 
RUFY4 GBP6a C2a 
ETV7b HIST1H3C CARD17 
TCN2 SLC2A14 EXOC3L1a 
LGALS3BP TICAM2 RHOV 
EXOC3L1a GBP5 AOC1 
COL23A1 C1QCb KCNMA1 
MT2A TAS2R60 FAM26F 
BATF2b ANKRD22a KCNJ10 
CXCL10 CH17-296N19.1 CD274 
SCT HIST1H4C SDC3 

Top 30 ranked genes selected by log2 fold change and FDR P = 0.05: 30 genes out of 47 coding DEGs in incipient TB; 30 genes out of 233 coding DEGs in subclinical TB; 30 genes out of 311 coding DEGs in clinical TB. No footnote: genes are unique to each of incipient, subclinical, and clinical top 30 genes expressed, although expressed in all datasets at lower levels.

a

Common in two out of three of the 30-gene signatures.

b

Common in all three 30-gene signatures.

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