Figure 6.
Glial morphology appears intact in TGFβ knockdown animals. (A) Axons (green) and glia (magenta) in control and pan-glial TGFβ knockdown animals from 4- (top) and 28-(bottom)-d-old L1 nerves. (B) Nerves from WG-specific TGFβ knockdown animals from 4- (top) and 28-(bottom)-d-old L1 nerves. (C–E) Electron micrographs of a cross section of the L1 nerve at 28 d from control (C), babo (D), and Smox (E) knockdown animals. Wrapping glia are highlighted in cyan. (F) Quantification of the wrapping index ([individually wrapped axons + bundles of axons]/total axons). Mean ± 95% CI. One-way ANOVA with Sidak’s multiple comparisons test, n = 4–5 per condition. ns, not significant.