Figure 9.
Blocking TGFβ signaling alters wrapping glial metabolism and support of axons. (A) ATP sensor signal in wrapping glia (WG) in the L1 nerve. Asterisks indicate WG nuclei. (B) Quantification of the cytosolic ATP sensor intensity (n = 64 [control], 24 [baboRNAi], 18 [SmoxRNAi], 32 [srlOE], 18 [BsgRNAi]). (C) Quantification of intact neuron cell bodies from aged, 28-day animals from control, srlOE, or BsgRNAi expressed in WG n = 23 (control), 27 (srlOE), 29 (BsgRNAi). Genotypes are as indicated. Mean ± 95% CI. One-way ANOVA with Tukey’s multiple comparisons test, n = 78. **, P < 0.01; ****, P < 0.0001.